Mini Review

Phenotypic differences in Obese Patients with Heart Failure with Preserved Ejection Fraction (HFpEF) - A Mini Review

Michelle Nanni*, Vivian Hu, Swagata Patnaik, Alejandro Folch Sandoval and Johanna Contreras

Published: 24 January, 2024 | Volume 8 - Issue 1 | Pages: 001-005

The incidence of heart failure with preserved ejection fraction (HFpEF) continues to rise, and obesity continues to be a predominant comorbid condition affecting patients with HFpEF. Recent research sheds light on the important pathophysiologic role that obesity plays in the development of HFpEF, with many areas of opportunity existing for future developments in understanding the etiology and management of the disease. Crucial in these pathophysiologic developments are studies that clearly characterize the obesity phenotype in HFpEF and compare it to presentations of HFpEF in patients without obesity. This paper reviews the existing literature on the obesity phenotype within HFpEF and discusses some of the prevailing ideas behind the pathophysiologic interplay between the conditions, as well as the existing treatments demonstrating improved outcomes in HFpEF.

Read Full Article HTML DOI: 10.29328/journal.niogb.1001020 Cite this Article Read Full Article PDF


HFpEF; Obesity; Obesity phenotype; Cardiovascular imaging; Diastolic dysfunction; Systolic dysfunction; Echocardiography; Heart failure


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