https://www.obesitygenejournal.com/feed Introduction Obesity is defined as excess adipose tissue. Obesity is a concerned body condition where an individual accumulates so much body fat that has negative impact on his health. Diabetes is a condition where the amount of glucose in our blood is too high and our body cannot use it properly. Metabolic syndrome is not a disease in itself. Instead, it's a group of risk factors such as high blood pressure, high blood sugar, unhealthy cholesterol levels, and abdominal fat. When these risk factors combine, they set the stage for serious problems such as heart attacks and strokes. New Insights in Obesity: Genetics and Beyond publishes stringently peer-reviewed manuscripts connecting healthcare professionals world-wide to counter the global challenge of obesity, diabetes and metabolic syndrome. New Insights in Obesity: Genetics and Beyond provides a unique global podium to publish latest and updated research findings to prefigure a role in discovering cures for diabetes, obesity and related metabolic syndrome and pushing the demand for innovative reagents for research. Reasons for Publishing Diabetes is one of the most challenging health problems in the 21st century. On the other hand, obesity has also become a world-wide rampant issue. It is estimated that if current obesity trends continue, by the year 2030, 86.3% of adults will be overweight or obese and 51.1% will be obese and by 2048 all adults will be overweight or obese. Moreover, diabetes & obesity are major contributors for adverse metabolic effects on blood pressure, cholesterol, triglycerides and insulin resistance. Therefore, perceiving the futuristic threat and consequences, New Insights in Obesity: Genetics and Beyond got committed to publish manuscripts providing insights on controlling aspects for metabolic syndrome, equally increasing knowledge as well as stimulating research in the related fields. Research Article Mahdi Nowroozi 2025-09-09 15:10:17 One of the most important and critical red blood cell disorders is dysfunction and deformation of the membrane structure, which affects the metabolic and biological red blood cell functions. On the other hand, the basic causes of these problems are the genetic mutations in the production of proteins that correlate to the structure and receptors of cells. The diagnosis methods and techniques are the other essential points that focus most scientists on. In this systematic review, the article pointed to the key title, which is the diagnosis of novel genes with different techniques and methods. The result of articles studies that were published in the last decades underlined the types of techniques such as Whole-Exome Sequencing, Quantitative Real-Time PCR, Targeted Next-Generation Sequencing, and Sulphate-Polyacrylamide Gel, which investigated the different membraned gene mutations that are novel and correlated to the genes that make the structures and functions of red blood cells such as hereditary spherocytosis, hereditary elliptocytosis, hereditary pyro poikilocytosis. In addition, the hereditary membrane disorders correlated to others, such as hereditary spherocytosis, have a relationship with vitamin B12, immunodeficiency. https://www.obesitygenejournal.com/articles/niogb-aid1023.pdf Review Article Kulvinder Kochar Kaur 2025-07-24 10:14:09 https://www.obesitygenejournal.com/articles/niogb-aid1022.pdf Mini Review Shashikanth Kharat*, Sanjana Mali* 2024-02-27 14:48:32 Stevia is a natural sweetener that has gained attention as a potential sugar substitute for glycemic control and weight management. Extensive research has shown that high sugar consumption is linked to obesity, dental caries, and other health issues. Stevia, derived from the Stevia rebaudiana plant, offers sweetness without calories and has a favorable glycemic profile. Studies have demonstrated its effectiveness in regulating blood glucose levels and reducing overall sugar and caloric intake. Consumer attitudes suggest a positive reception of Stevia as a sugar substitute among health-conscious individuals. However, further research is needed to understand its long-term effects and consumer sentiments. Future investigations should prioritize human clinical trials, targeted studies in diabetic populations, and exploration of Stevia’s interaction with gut microbiota, among other aspects. Stevia shows promise as a health-conscious alternative in glycemic control and weight management. https://www.obesitygenejournal.com/articles/niogb-aid1021.pdf Mini Review Michelle Nanni*, Vivian Hu, Swagata Patnaik, Alejandro Folch Sandoval, Johanna Contreras 2024-01-24 10:02:20 The incidence of heart failure with preserved ejection fraction (HFpEF) continues to rise, and obesity continues to be a predominant comorbid condition affecting patients with HFpEF. Recent research sheds light on the important pathophysiologic role that obesity plays in the development of HFpEF, with many areas of opportunity existing for future developments in understanding the etiology and management of the disease. Crucial in these pathophysiologic developments are studies that clearly characterize the obesity phenotype in HFpEF and compare it to presentations of HFpEF in patients without obesity. This paper reviews the existing literature on the obesity phenotype within HFpEF and discusses some of the prevailing ideas behind the pathophysiologic interplay between the conditions, as well as the existing treatments demonstrating improved outcomes in HFpEF. https://www.obesitygenejournal.com/articles/niogb-aid1020.pdf Short Communication Grechkanev GO,Soshnikov AV,Nikishov NN 2023-03-16 14:24:27 The aim of the study was to evaluate ozone therapy in obese pregnant women. 118 pregnant women with varying degrees of obesity were examined and treated. It turned out that the course of intravenous drip administration of ozonated saline solution leads to the normalization of a number of important indicators of homeostasis including stimulation of the antioxidant system and reduction of peroxide stress. The reduction in the frequency of miscarriage, preeclampsia, premature birth, and bleeding during childbirth and the postpartum period is achieved. It`s possible to recommend the inclusion of ozone therapy in the preventive treatment of pregnant women with exogenous constitutional obesity. https://www.obesitygenejournal.com/articles/niogb-aid1019.pdf Research Article Guillermo Padrón-Arredondo 2022-05-06 11:58:11 Background: From the first COVID-19 case in Playa del Carmen, 370 cases of infection have been reported in our staff until December 31, 2020. Material and methods: Study in workers of the General Hospital who developed SAR-CoV-2 infection during the pandemic. A sample of 30 cases of both sexes with laboratory-confirmed infection was obtained. Descriptive statistics were used with measures of central tendency, dispersion and percentages. Results: In a sample of 30 workers there were 13 doctors, 6 nurses and 11 support workers. The age was obtained as a mean of 38.8 years and SD = 10.4. Only four risk factors were found. Of the 30 infected health workers, 27 were treated on an outpatient basis and three required hospitalization. Discussion: The main symptoms in health workers are alterations in the sensation of taste and smell, but unlike our study, was headache, fever and myalgia. Likewise, it has been observed that medical are the most affected, but in this study it was support and the least affected was nursing personnel. There is no doubt that asymptomatic carriers are a serious disease transmission problem such that transmission between health workers by asymptomatic carriers is possible as was observed in this analysis. https://www.obesitygenejournal.com/articles/niogb-aid1018.pdf Review Article N Pérez,C Serra,R Bou,M Ortín,A Baltasar 2022-03-09 15:20:16 Laparoscopic biliopancreatic diversion with duodenal switch (BPD-DS) is a technically challenging operation that requires extensive surgical dissection, transection and restoration of intestinal continuity, and advanced laparoscopic suturing skills. https://www.obesitygenejournal.com/articles/niogb-aid1017.pdf Review Article Alexander V Sirotkin 2021-04-26 00:00:00 This non-systematic review outlines the current knowledge concerning provenance, chemical composition and properties of apple cider vinegar, its general health effects, as well as the currently available knowledge concerning its action on fat storage, physiological mechanisms of its effects, as well as its safety and recommended dosage for treatment of obesity.  https://www.obesitygenejournal.com/articles/niogb-aid1016.pdf Review Article Mohamadreza Alivand,Beitullah Alipour,Sara Moradi,Yaser Khaje-Bishak,Maedeh Alipour 2021-01-19 00:00:00 Understanding the obesity-related genes may provide future therapeutic strategies to modulate disease progression. UCP2 separates oxidative phosphorylation (OXPHOS) from ATP production in the inner mitochondria. Figure 1 shows the differences among UCP1, 2, 3. The main role of UCP2 is controlling the metabolism of energy in the cells [1-3]. Besides that, the expression of UCP2 is associated with chronic inflammation due to reactive oxygen species (ROS). In this regard, in injured cells and tissues, ROS could be decreased by reducing the proton motor force by the anti-inflammatory effect of UCP2 [4]. https://www.obesitygenejournal.com/articles/niogb-aid1015.pdf Editorial Alijani Sepideh,Arefhosseini Seyedrafie 2020-12-14 00:00:00 The well recognized white adipose tissue is an endocrinal organ secreting various hormones and this article simply indicates to the physiologic concepts brown fat tissues (BAT) which are extremely active endocrine organs and play various metabolic active roles in intermediate metabolism. The physiologic function of Brown adipose tissues contributes to energy-producing parts of the cell. Its amount is rare up to approximately one hundred and thirty gram and implies important characteristics for mammals. An increase in energy expenditure could be an aim by activation of BAT, seems futurity to reduce body weight that needs a vast majority of fundamental research to facilitate its occurrence [1]. Brown fat tissue generates heat and has valuable importance for human metabolism [2,3]. Brown fat tissue is decreased in overweight and obese people and possibly activating brown fat tissue might help for reducing weight and weight-related metabolic disorders like insulin resistance. https://www.obesitygenejournal.com/articles/niogb-aid1014.pdf Review Article Aniceto Baltasar 2020-04-28 00:00:00 Obesity is a multifactorial epidemic disease of environmental origin that affects subjects of all countries and whose origin is not in the stomach or intestines. Surgical treatment represents a unique case of surgery for operating healthy organs, which are not the cause of the disease and do not improve after the operation. Kremen and Linner [1] and Varco and Buchwald teams of in Minneapolis, MN began the intestinal deviation (ID) of malabsorption in 1954. Payne [2] and Scott [3] developed these ID techniques in the 1960s leaving only 14- 4 inches (35 -10 cm) as an absorption zone and were abandoned in the 1970s due to its serious metabolic (malnutrition) and liver complications (liver failure). https://www.obesitygenejournal.com/articles/niogb-aid1013.pdf Research Article Molly Jacobs 2020-04-22 00:00:00 Introduction: Recent research has explored the role that personality traits play in health and weight determination. This study extends current research by evaluating the extent to which behavior mediates the impact of neuroticism and body weight using polygenic risk as a measure of neurotic tendency. Methods: Structural equation modelling disaggregates the effect of neurotic tendency on BMI into direct and indirect effects. Indirect effects-those transmitted through mediating health behaviors—allow for the simultaneous comparison of multiple behavioral mediators— exercise frequency, smoking intensity, sleep sufficiency and screen time. Results: While health-related behavior-screen time, sleep, smoking and exercise-directly influence BMI, neurotic tendency showed no direct effect. The strong association between neurotic tendency and behavior, however, indicated that polygenic risk of neuroticism indirectly influenced BMI through two health related behaviors-screen time and smoking. Therefore, the relationship between neurotic disposition and BMI is transmitted through behavioral pathways rather than directly. Conclusion: This research offers novel insight into the relationship between personality and health outcomes. If behavior manifests through personality disposition, then understanding the relationship between personality, behavior and BMI will help guide weight management interventions to focus on strategies to help manage responses to stress to elicit desired weight outcomes. https://www.obesitygenejournal.com/articles/niogb-aid1012.pdf Research Article Manish Motwani,Rajeev Palvia,Bhavesh Nanda,Mahek Motwani,Bhakti Chaubal,Jyoti Kesarkar, Bhakti Mange,Sneha Shukla 2020-03-27 00:00:00 The childhood obesity is increased more than three folds in last two decades in developed world. There is nutritional transition seen in the developing world including India. The westernization in diet of the Indian population along with prosperity brings the brunt of overweight and obesity. This has future implications of liver diseases, heart diseases, hypertension, hyperlipidaemia, insulin resistance; malignancies. Mumbai is the prosperous city and an economical capital of India. Also, the rampant use junk food, common outdoor eating’s, no grounds to play for children make the high likelihood that the prevalence of obesity to be higher than rest of the country. It can profoundly affect children’s physical health, social, and emotional well-being and self-esteem. It is also associated with poor academic performance and a lower quality of life experienced by the child. One of the best strategies to reduce childhood obesity is to improve the eating and exercise habits of the entire family. Treating and preventing childhood obesity helps protect the child’s health and has tremendous impact on child’s Physical and academic performance. And hence we at Aastha Bariatrics took initiative and launched ECHO... for a change (‘E’radicating ‘C’Hild ‘H’ood ‘O’besity), a pan Mumbai campaign against childhood obesity. This campaign was done in 15 high schools across Mumbai, which covered in total of 9000 students. https://www.obesitygenejournal.com/articles/niogb-aid1011.pdf Opinion Sahithi G 2019-12-31 00:00:00 The main disturbing situation faced by any individual is obesity nowadays. Obesity occurs because of overweight and this has several reasons to gain weight like hereditary, diabetes, diet, aging, PCOS in women, stress, and tiredness. It is a major, sustaining, worsening condition of energy regulation with severe hereditary and early life natural causes. However, there are ways that we can treat obesity, but the complication emerges with the side effects. One way of treating obese by using lifestyle intervention involving exercise, maintaining a proper diet, and pharmacotherapy. Following this method does not affect much as mostly it includes lifestyle intervention. However, by using lifestyle intervention we could reduce weight to a certain extent only. https://www.obesitygenejournal.com/articles/niogb-aid1010.pdf Research Article Marwan O Jalambo,Basil Kanoa,Mohammed S Ellulu,Smaher Younis,Mueen El-Kariri 2018-12-04 00:00:00 Background: The fundamental cause of obesity and overweight is an energy imbalance between calories consumed and calories expended. Aim: To clarify and figure out food habits and different lifestyle pattern among a sample of Palestinian women attending the nutrition center in the Gaza Strip. Methods: A cross-sectional study involved 116 women were randomly chosen by purposive census sampling. They aged 25 to 60 years with a diagnosis of obesity. The data collected by interview questionnaire that included social factors, lifestyle habits, and health/disease history. Results: Age group variable has distributed significantly (p=0.024), (31.0%) of morbid obese were ≥35 years group compared to (13.5%) of morbid obese amongst the younger group. The higher intakes of legumes (OR: 2.134, P=0.003), nuts (OR: 3.917, P=0.019), eggs (OR: 6.840, P=0.009), fast foods (OR: 4.461, P=0.005), and soda drinks (OR: 2.230, P=0.004) were the risk factors linked to the increased risk of morbid obesity. Moreover, the higher intakes of legumes (OR: 8.439, P=0.011), eggs (OR: 6.900, P=0.041), chips (OR: 5.049, P=0.012), sugar (OR: 2.068, P=0.011), and fast foods (OR: 3.029, P=0.025) are risk factors of chronic diseases. Conclusion: The study identified several lifestyle factors and improper dietary habits associated with obesity among women in Gaza city. There is a great need to change these habits to avoid the increased risk of obesity. Gene-environment interaction can explain the high incidence of obesity. A national plan of action to overcome obesity is urgently needed to reduce its economic and health burden https://www.obesitygenejournal.com/articles/niogb-aid1009.pdf Review Article Preeti Singh 2018-11-30 00:00:00 Heftiness, a mind boggling interchange among ecological and hereditary factors and is related with critical horribleness and mortality. Utilization of herbs for the administration of heftiness in the ongoing occasions is pulling in consideration. A web and manual based writing overview was led to survey the measure of data accessible on the natural items for weight administration. Customary writing, PubMed, Scopus, Google researcher databases were screened up to February 2012. The pursuit words were “stoutness”, “home grown medication/items/separates”, “restorative plants”, “customary drug”, “Ayurvedic prescription” without narrowing/constraining looking words or components. Distributions just with edited compositions/full articles and books were inspected in the pursuit. In light of the accessible writing, for huge numbers of the natural and weight reduction items, there is minimal distributed data and there have been no clinical preliminaries or the level of proof is restricted. Our writing study additionally demonstrated that these home grown items fall under an adequate level of proof or with no scientific foundation by any stretch of the imagination, or they have a logical discerning however not to an acknowledgment level. Endeavors were made in the audit to characterize the highlights of conceivable natural weight reduction item. A perfect home grown enemy of stoutness item ought to diminish the weight by 10% over fake treatment of treatment by demonstrating a proof of change of bio markers like blood pres-beyond any doubt, lipids and glycemia with no reactions. https://www.obesitygenejournal.com/articles/niogb-aid1008.pdf Research Article Guillermo Padrón Arredondo 2018-01-26 00:00:00 Introduction: Most police officers work long hours in day and night shifts and this exposure can harm your health. Objective: Know the Body Mass Index (BMI) of a group of policemen of both sexes chosen at random to calculate the degree of overweight / obesity of the observed population. Material and Method: An cross-sectional study was carried out on 75 elements of the municipal police of sexes, obtaining age, height, and weight with which the corresponding Body Mass Index was obtained. Descriptive statistics were used. Results: Measurements were taken at 75 (100%) policemen of both of them sexes, 60 (80%) male and 15 (20%) female. And the following results were obtained: ideal weight 5 (6.6%), overweight 21 (28.0%) elements and obesity 49 (65.3%). Discussion: Obese workers are prone to getting sick, missing work, disability and early retirement when compared to non-obese workers. Obesity can be a predictor of early mortality; therefore, with a BMI of 30-35, life expectancy decreases from 2 to 4 years and with a BMI of 40-45 it decreases from 8 to 10 years. In our study we found 70 (93.3%) policemen were overweight and obese BMI> 25). Conclusions: Our findings recommend the implementation of diverse programs for the improvement of the health of this labor group with a multidisciplinary team as well as the adequate physical spaces for the practice of the corresponding activities. https://www.obesitygenejournal.com/articles/niogb-aid1007.pdf Research Article Timothy R Koch,Timothy R Shope,Matthew E Sharbaugh 2017-10-31 00:00:00 In 1955, nutrient malabsorption following upper gut surgery was shown to be related to altered upper gut microbiome. In individuals with abdominal symptoms after Roux-en-Y gastric bypass, we have reported that small intestinal glucose malabsorption is associated with upper gut bacterial overgrowth. We hypothesize that individuals with abdominal symptoms after vertical sleeve gastrectomy have glucose malabsorption associated with upper gut bacterial overgrowth, and to test this hypothesis, bacterial overgrowth and potential glucose malabsorption are examined after sleeve gastrectomy. This is a retrospective study of individuals with medically-complicated obesity who underwent sleeve gastrectomy from 2013 to 2016 with subsequent glucose hydrogen breath testing to evaluate abdominal symptoms. A fasting breath hydrogen or methane of ≥10 PPM or rise of ≥8 PPM ≤45 minutes after oral glucose is bacterial overgrowth, while glucose malabsorption is a second rise of ≥8 PPM at >45 minutes. Seven females (mean age: 48.0 years; mean body mass index at surgery: 45.7 kg/m2) are described. Five subjects (71%) have an early rise in hydrogen or methane, while three (43%) have a second rise in hydrogen or methane >45 minutes after glucose. The mean percent excess weight loss at one year was 40% in three individuals with a second peak and 46% in four subjects without a second peak. After sleeve gastrectomy, subjects have glucose malabsorption associated with the presence of bacterial overgrowth. Completion of a larger prospective study is needed to confirm and expanding upon these findings. Further work should examine the potential effects of bacterial overgrowth on expression of intestinal glucose transporters. https://www.obesitygenejournal.com/articles/niogb-aid1006.pdf Research Article Renato Vidal Linhares,Felipe Monnerat Marino Rosa,José Quaresma,João Regis Ivar Carneiro,Valéria Bender Braulio,Roberto Simão,Denise Pires de Carvalho,osé Fernandes Filho 2017-08-23 00:00:00 Introduction: Number of obese people is growing on a daily basis in Brazil, including morbid obese ones, but there is still a lack of studies with this subject. Due to this, the main goal of this study was to identify body profile, physiological variables behavior and oxygen consumption in grade III obese women, submitted to an ergospirometric test in arm ergometer. Method: Take part in this study, thirteen (13) female grade III obese patients between 20 and 40 years. They were submitted to an electric bioimpedance test for body composition measurement and an Ergospirometric test in arm ergometer for oxygen consumption, heart rate, and oxygen saturation, systolic and diastolic arterial pressure, resting and after exercises, analysis. Results: The patients revealed a BMI of 46.5±3.81 kg/m², 51.9±1.59% of body fat percentage. The patients reached 168.2±4.57bpm of heart rate, didn’t make any hypertensive response to the effort reaching an arterial pressure of 171.1±22.15mmHg x 87.5±4.18mmHg. Oxygen saturation was 98±0.71% and oxygen consumption peak was, also in average, 12.3±2.75ml.kg.min-1. Conclusion: It was verified that there was no oxygen saturation drop nor hypertensive response and all of the patients reached the maximum heart rate.  https://www.obesitygenejournal.com/articles/niogb-aid1005.pdf Research Article Roberto Carlos Burini,Hugo Tadashi Kano,Mariana Santoro Nakagaki,Patricia Baston Frenhani,Katia Cristina Portero-McLellan 2017-07-25 00:00:00 The etiology of abdominal obesity is multifactorial and has environmental factors as its most expressive risk factors. This study cross-sectional analyzed the association of abdominal fatness with physical inactivity and food inadequacy of 1,557 subjects, both genders, over 35yrs. old, enrolled in an ongoing epidemiological study. Waist circumference (WC) was the primary variable and demographic, social-economic, anthropometric and dietary intake data, were the co-variables. NCEP-ATP III, WHO, IPAQ-long (version 8) and Healthy Eating Index were used for functional definition of variables. Furthermore, longitudinal data from 50 subjects in an exercise protocol for 10 week receiving either regular diet (G1, n=22) or 30g fiber adequacy (G2; =28), were analyzed. The performed statistical analyses used software SAS for Windows, version 9.1 with p=0.05. In a predominantly female sample (74%), 76% aging 35-60yrs, 64% completed elementary school, 73% were living in a low income household, 77.5% overweight. The 62.5% presenting altered WC values were predominantly older, presented higher body fatness, and were consuming low variety-poor quality diet rich in fat (mainly saturated) and lower in fruit. WC correlated negatively with fruit intake and aerobic capacity (VO2max) but only carbohydrate (positive) and fruit intake (negative) were considered independent risk factors for abdominal obesity. In the longitudinal study, both G1 and G2 groups were similar at baseline and G1 maintained the anthropometry values throughout the experiment. Conversely, G2 decreased total body (4%) and WC (7%) fatness, reducing severe obesity by 16%, minimally affecting overweight and eutrophic rates. G2 presented 211% increase in fiber intake and 150% increase in plasma beta-carotene (colorful-fiber marker). Thus, in conclusion, recommended dietary fiber intake (increased fruit and low CHO intake) and physical activity would be the recommended changes against abdominal obesity and, by associating both physical exercises and dietary fiber there was indeed a decrease in abdominal fatness and obesity, predominantly at its higher grade. https://www.obesitygenejournal.com/articles/niogb-aid1004.pdf Short Communication Antonio Eduardo de Aquino Jr,Fernanda Mansano Carbinatto 2017-06-20 00:00:00 Introduction: Obesity is a global-level epidemic. Together with this disease, called chronic subclinical inflammatory disease, many other diseases, known as comorbidities, arise. Objective: To show that the association between low-level laser therapy and physical exercise is supported, by experimental and clinical studies, being an instrument that maximizes the treatment of obesity as well as its comorbidities. Conclusion: This manuscript brings a compendium of accomplished work by our group that allows understand the mechanism base of interaction between the photonic technology and the physical exercise, allowing to potentiate the treatment of the obesity. https://www.obesitygenejournal.com/articles/niogb-aid1003.pdf Short Communication Mário Augusto Paschoal 2017-05-23 00:00:00 Alterations in cardiac autonomic modulation of children and obese preadolescents have attracted the attention of researchers around the world. These alterations cause disorders in the cardiac autonomic control and can interfere in cardiac output and in the homeostatic actions that depends on the cardiovascular system action. https://www.obesitygenejournal.com/articles/niogb-aid1002.pdf Case Report Angelo Michele Carella,Teresa Marinelli,Armando Melfitano,Michele Di Pumpo,Matteo Conte,Angelo Benvenuto 2017-02-09 00:00:00 Ginseng extracts are often used as adaptogen to improve mental performances and well being, helping to overcome stress. Thus, in our times a lot of ginseng extracts are continuously produced and sold into commercial channels. Both Asian and Korean red ginseng (Panax ginseng) and American ginseng (Panax quinquefolius) are the most extensively used and researched. Both Panax ginseng and Panax quinquefolium contain different types of saponins, also known as ginsenosides, which are the substances that give ginseng medicinal properties. Human and animal studies showed that ginseng extracts can also have hypoglycemic effects. The mechanisms by which ginseng reduces blood glucose levels are unclear; some mechanisms have been proposed to explain its hypoglycemic effect, especially modulating effects on insulin sensitization and/or insulin secretion and regulating actions on digestion and intestinal absorption. We describe a case of hypoglycemia by ginseng in type 2 diabetic patient treated with oral hypoglycemic agents. Although, in order to provide better assessments of a sure anti-diabetic efficacy of ginseng, larger and longer randomized controlled clinical trials will be required, in our case we think that we have enough evidence to believe that the cause of hypoglycemia was ginseng. Obviously, this report should not be taken as a proof of the hypoglycemic effect of ginseng, nor it wants to be a suggestion to use ginseng in the treatment of diabetes; instead, it wants to be an alert for patients and clinicians to avoid hypoglycemia in daily clinical practice. https://www.obesitygenejournal.com/articles/niogb-aid1001.pdf