Review Article

The review of the relationship between UCP2 and obesity: Focusing on inflammatory-obesity

Mohamadreza Alivand*, Beitullah Alipour*, Sara Moradi, Yaser Khaje-Bishak and Maedeh Alipour

Published: 19 January, 2021 | Volume 5 - Issue 1 | Pages: 001-013

Understanding the obesity-related genes may provide future therapeutic strategies to modulate disease progression. UCP2 separates oxidative phosphorylation (OXPHOS) from ATP production in the inner mitochondria. Figure 1 shows the differences among UCP1, 2, 3. The main role of UCP2 is controlling the metabolism of energy in the cells [1-3]. Besides that, the expression of UCP2 is associated with chronic inflammation due to reactive oxygen species (ROS). In this regard, in injured cells and tissues, ROS could be decreased by reducing the proton motor force by the anti-inflammatory effect of UCP2 [4].

Read Full Article HTML DOI: 10.29328/journal.niogb.1001015 Cite this Article Read Full Article PDF


UCP2; Metabolism; Obesity; ROS; Inflammation


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